Autophagy, inflammation and neurodegenerative disease
نویسندگان
چکیده
منابع مشابه
Autophagy and neurodegenerative disorders
Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or i...
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Target of rapamycin (TOR) signaling is a regulator of cell growth. TOR activity can also enhance cell death, and the TOR inhibitor rapamycin protects cells against proapoptotic stimuli. Autophagy, which can protect against cell death, is negatively regulated by TOR, and disruption of autophagy by mutation of Atg5 or Atg7 can lead to neurodegeneration. However, the implied functional connection ...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2010
ISSN: 0953-816X
DOI: 10.1111/j.1460-9568.2010.07500.x